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Drug Information

Lipase , Amylase , Protease Oral capsule, gastro-resistant sprinkles

What is this medicine?

PANCRELIPASE (pan cre LI pase) helps to improve digestion of food by replacing digestive enzymes. This medicine is used to treat health conditions that cause your body to produce less of these enzymes.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • a history of intestinal blockage or a condition called 'fibrosing colonopathy'

  • abnormally high uric acid in the blood

  • diabetes

  • gout

  • kidney disease

  • trouble swallowing capsules

  • an unusual or allergic reaction to pancrelipase, pancreatin, pork, pork protein, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take with food. Do not crush or chew the contents of the capsule. If you or your child have trouble swallowing, you may open the capsule and sprinkle the contents on soft foods that do not require chewing such as applesauce, pureed bananas, or pears. Swallow the mixture right away followed with water or juice. Do not store the mixture. If you are giving this medicine to an infant, you may sprinkle the contents directly into your child’s mouth. Give the medicine right before each feeding of formula or breast milk. Do not mix capsule contents directly into formula or breast milk. Make sure the medicine is swallowed completely and that no medicine is left in the mouth. Take your doses at regular intervals. Do not take your medicine more often than directed.

A special MedGuide will be given to you by the pharmacist with each prescription and refill of delayed-release capsules (Creon, Zenpep, or Pancreaze). Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. While this medicine may be prescribed for children for selected conditions precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

  • acarbose

  • antacids containing calcium or magnesium

  • iron

  • miglitol

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Visit your doctor for regular check ups. Talk to your doctor before you change brands of this medicine. Each brand has different amounts of enzymes.

You may need to be on a special diet while taking this medicine. Also, ask your doctor how much water you need to drink.

This medicine may increase your chance of having a rare bowel disorder. The risk of having this condition may be reduced by following the dosing directions that your healthcare professional gives you. Call your healthcare professional right away if you have any unusual or severe stomach pain.

This medicine may increase blood uric acid levels, for example, worsening of gout, or painful, swollen joints. Call your healthcare professional right away if you have any of these symptoms.

Be careful if you open the capsule. This medicine can irritate the lungs if you breathe it in. Also, do not hold the medicine in your mouth or chew it. This may cause mouth sores.

This medicine may affect blood sugar levels. If you have diabetes, check with your doctor or health care professional before you change your diet or the dose of your diabetic medicine.

Women should inform their doctor if they wish to become pregnant or think they might be pregnant.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • fever or chills, sore throat

  • severe stomach pain or bloating

  • shortness of breath

  • skin rash

  • trouble passing stool

  • vomiting

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • constipation or diarrhea

  • cough

  • dizziness

  • headache

  • nausea

  • stomach gas

  • stomach pain

  • weight loss

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 25 degrees C (59 and 77 degrees F). Do not refrigerate. Protect from moisture. Throw away any unused medicine after the expiration date.


Lipase , Amylase , Protease Oral powder

What is this medicine?

PANCRELIPASE (pan cre LI pase) helps to improve digestion of food by replacing digestive enzymes. These enzymes are produced by the pancreas. Some health conditions may cause your body to produce less of these enzymes.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • an unusual or allergic reaction to pancrelipase, pancreatin, pork, pork protein, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

How should I use this medicine?

Take this medicine by mouth. Follow the directions on the prescription label. Take with food. Mix the powder with small amounts of fruit juice or soft foods that do not require chewing like applesauce, instant pudding, or gelatin. Do not mix in milk, ice cream, or other dairy products. Swallow the dose right away. Do not chew or hold the dose in your mouth. Drink plenty of water or juice after the dose. Take your doses at regular intervals. Do not take your medicine more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. While this medicine may be prescribed for children for selected conditions precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

  • acarbose

  • antacids containing calcium or magnesium

  • miglitol

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Ask your doctor or health care professional before you change your brand of your medicine. Each brand of this medicine contains different amounts of enzymes and may not give the same results.

Drink plenty of fluids while taking this medicine. Follow the instructions of your health care professional regarding your diet.

Do not hold the powder in your mouth. This may cause mouth sores.

Do not breathe in the powder. This can irritate the lungs and could cause an asthma attack.

If you spill this medicine on your hands and skin, rinse off with plenty of water. It may cause irritation, itching, or burning.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • shortness of breath

  • vomiting

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • constipation or diarrhea

  • nausea

  • stomach pain

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature below 25 degrees C (77 degrees F). Protect from moisture. Keep container tightly closed. Throw away any unused medicine after the expiration date.


Lipase , Protease , Amylase Oral capsule, gastro-resistant pellets

What is this medicine?

PANCRELIPASE (pan cre LI pase) helps to improve digestion of food by replacing digestive enzymes. This medicine is used to treat health conditions that cause your body to produce less of these enzymes.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • a history of intestinal blockage or a condition called 'fibrosing colonopathy'

  • abnormally high uric acid in the blood

  • diabetes

  • gout

  • kidney disease

  • trouble swallowing capsules

  • an unusual or allergic reaction to pancrelipase, pancreatin, pork, pork protein, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take with food. Do not crush or chew the contents of the capsule. If you or your child have trouble swallowing, you may open the capsule and sprinkle the contents on soft foods that do not require chewing such as applesauce, pureed bananas, or pears. Swallow the mixture right away followed with water or juice. Do not store the mixture. If you are giving this medicine to an infant, you may sprinkle the contents directly into your child’s mouth. Give the medicine right before each feeding of formula or breast milk. Do not mix capsule contents directly into formula or breast milk. Make sure the medicine is swallowed completely and that no medicine is left in the mouth. Take your doses at regular intervals. Do not take your medicine more often than directed.

A special MedGuide will be given to you by the pharmacist with each prescription and refill of delayed-release capsules (Creon, Zenpep, or Pancreaze). Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. While this medicine may be prescribed for children for selected conditions precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

  • acarbose

  • antacids containing calcium or magnesium

  • iron

  • miglitol

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Visit your doctor for regular check ups. Talk to your doctor before you change brands of this medicine. Each brand has different amounts of enzymes.

You may need to be on a special diet while taking this medicine. Also, ask your doctor how much water you need to drink.

This medicine may increase your chance of having a rare bowel disorder. The risk of having this condition may be reduced by following the dosing directions that your healthcare professional gives you. Call your healthcare professional right away if you have any unusual or severe stomach pain.

This medicine may increase blood uric acid levels, for example, worsening of gout, or painful, swollen joints. Call your healthcare professional right away if you have any of these symptoms.

Be careful if you open the capsule. This medicine can irritate the lungs if you breathe it in. Also, do not hold the medicine in your mouth or chew it. This may cause mouth sores.

This medicine may affect blood sugar levels. If you have diabetes, check with your doctor or health care professional before you change your diet or the dose of your diabetic medicine.

Women should inform their doctor if they wish to become pregnant or think they might be pregnant.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • fever or chills, sore throat

  • severe stomach pain or bloating

  • shortness of breath

  • skin rash

  • trouble passing stool

  • vomiting

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • constipation or diarrhea

  • cough

  • dizziness

  • headache

  • nausea

  • stomach gas

  • stomach pain

  • weight loss

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 25 degrees C (59 and 77 degrees F). Do not refrigerate. Protect from moisture. Throw away any unused medicine after the expiration date.


Lipase , Protease , Amylase Oral tablet

What is this medicine?

PANCRELIPASE (pan cre LI pase) helps to improve digestion of food by replacing digestive enzymes. This medicine is used to treat health conditions that cause your body to produce less of these enzymes.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • an unusual or allergic reaction to pancrelipase, pancreatin, pork, pork protein, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take with food. Take your doses at regular intervals. Do not take your medicine more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. While this medicine may be prescribed for children for selected conditions precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

  • acarbose

  • antacids containing calcium or magnesium

  • iron

  • miglitol

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Visit your doctor for regular check ups. Talk to your doctor before you change brands of this medicine. Each brand has different amounts of enzymes.

You may need to be on a special diet while taking this medicine. Also, ask your doctor how much water you need to drink.

Be careful if you open the capsule. This medicine can irritate the lungs if you breathe it in. Also, do not hold the medicine in your mouth or chew it. This may cause mouth sores.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • shortness of breath

  • skin rash

  • vomiting

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • constipation or diarrhea

  • nausea

  • stomach pain

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature below 25 degrees C (77 degrees F). Protect from moisture. Keep container tightly closed. Throw away any unused medicine after the expiration date.